COMMD5/HCaRG overexpression inhibited tumor growth and angiogenesis in a homograft renal carcinoma mouse model by promoting de-phosphorylation of ErbB2/HER2, ErbB3/HER3, and EGFR, leading to inhibition of ErbB signaling pathways (39). The gene discussed is COMMD5; the disease is renal carcinoma.