COMMD5 and fibrolamellar hepatocellular carcinoma: In an integrative genomic analysis of a large series of patients with fibrolamellar hepatocellular carcinoma (FLC) using next-generation sequencing, SNP-array and whole-transcriptome analysis, the most frequent focally amplified locus was at 8q24.3 in 4/32 patients (12.5%) spanning several genes including COMMD5 (32).