Moreover, a positive association between GPER expression and several indicators of improved clinical prognosis, such as female sex, negative HBsAg, small tumor size (<5 cm), and low serum level of AFP (≤400 ng/ml), was observed in patients with HCC, and GPER-positive patients exhibited longer OS than GPER-negative patients. Here, GPER1 is linked to hepatocellular carcinoma.