ALK and neoplasm: Within the past few decades, the MYCN oncogene has been extensively and deeply studied, and more molecules have also been discovered to play important roles in tumor development, progression, and metastasis, including ALK (8), LMO1 (31, 32), LIN28B (33, 34), AURKA (35, 36), AIRD1A and ARID1B (2), etc. Besides, some gene inhibitors have been attempted to treat NB, like ALK and AURKA.