High age-adjusted IGF-I (T3: OR 2.00, 95% CI 0.92–4.37; Ptrend=0.086) as well as high age-adjusted IGFBP-3 levels (T3: OR 2.10, 95% CI 1.06–4.15; Ptrend=0.031) were associated with higher odds of breast cancer recurrence compared with low IGF-I or IGFBP-3 levels. The gene discussed is IGFBP3; the disease is breast carcinoma.