NEDD4 and cancer: The histone deacetylase Sirtuin 2 (SIRT2) reduces ubiquitin-proteasome pathway-induced N-Myc protein degradation in neuroblastoma and C-Myc protein degradation in pancreatic cancer through repressing NEDD4 gene transcription by directly binding to NEDD4 gene promoter, which contributes to upregulation of Myc oncoproteins and results in cancer cell proliferation (16).