Diarrhea [10 mg/kg arm: 37 (10%) vs. 3 mg/kg arm: 21 (6%)], colitis [10 mg/kg arm: 19 (5%) vs. 3 mg/kg arm: 9 (2%)], and increased alanine aminotransferase [10 mg/kg arm: 12 (3%) vs. 3 mg/kg arm: 2 (1%)] were accounted for the most common G3-4 treatment-related AEs. The gene discussed is GPT; the disease is colitis.