Diarrhea (16, 21, 31–33, 46), increased lipase (16, 20, 31–33), elevated alanine transaminase (ALT) (31, 32, 46), colitis (20, 31, 32), rash (16, 21), and anemia (21, 39) were commonly manifested among G3-4 AEs in patients received these monoclonal antibodies. The gene discussed is GPT; the disease is anemia.