Previous studies revealed Kurtosis derived from ADC maps correlated with p53 expression of the squamous cells in the head-and-neck of cases with carcinoma (HNSCC), and lower T2WIp10 or T2WIp25 correlated with hypoxia-inducible factor (HIF)-1α overexpression (17, 18). This evidence concerns the gene HIF1A and head and neck squamous cell carcinoma.