TDRG1 peptide action in seminoma mainly relies on the activation of PI3K/Akt/mTOR oncogenic signaling pathway, since it is able to positively regulate the expression levels of p-PI3K, p-Akt, and p-mTOR, as well as to affect the translocation of nuclear p-Akt (113). The gene discussed is AKT1; the disease is seminoma.