The objective of this study is to evaluate HLC pair suppression as a risk factor for bloodstream infections and early death in MM patients and compare it with the classical immunoparesis, i.e., suppression of the immunoglobulins not related to the monoclonal isotype (i.e. reduction of IgA and/or IgM in an IgG MM patient). This evidence concerns the gene CD40LG and Miyoshi myopathy.