Previously, eight de novo YWHAG mutations have been identified in patients with epileptic encephalopathy (EE), including Glu15Ala, Arg57Gly, Arg57Cys, Asp129Glu, Tyr133Ser, Leu177Ile, Asn178Asp in one patient each, and Arg132Cys recurrently in five unrelated cases (Kanani et al., 2020). This evidence concerns the gene YWHAG and ethylmalonic encephalopathy.