The enrichment results of the three genes (STX1A, PTX3, MMP9) showed that they were significantly enriched in the JAK-STAT signaling pathway, apoptosis, and cytokine-cytokine receptor interaction pathways, which may be related to GBM invasion, metastasis, and adhesion (Figures 9A–D; Zhu and Li, 2011; Trejo-Solís et al., 2018; Henrik Heiland et al., 2019). This evidence concerns the gene STX1A and glioblastoma.