The correlation between CRNDE gene and PTX3 and STX1A genes has not been correlated for the time being confirmation in the literature, but PTX3 has been shown to be associated with poor prognosis in gliomas (Locatelli et al., 2013), and in connection with our results, its upstream target marker may be the CRNDE gene. The gene discussed is PTX3; the disease is glioma.