This same study found that 12 of the 95 patients who did not have COVID-19 had IgG antibodies that cross-reacted with conserved parts of SARS-CoV-2, particularly S2 and N. Interestingly, one COVID-19 sample collected 16 days after symptoms cross-reacted with S of SARS-CoV-2 but not S1 of SARS-CoV-2, suggesting memory of HCoVs since epitopes other than SARS-CoV-2 S1 are more conserved. The gene discussed is PSMD1; the disease is COVID-19.