To clarify the host immune defense response against these two viruses (32, 33), numerous immune genes involved in virus infection have been characterized, such as IFN regulatory factor (IRF) 3 (34), IRF7 (35), mitochondrial antiviral signaling protein (MAVS) (36), stimulator of interferon genes (STING) (37), and cholesterol 25-hydroxylase (CH25H) (38). This evidence concerns the gene CH25H and viral infectious disease.