Inhalation of hydrogen gas significantly increased the survival rate of endotoxemia mice (Figure 1A), and improved lung injury and lung function, such as lung injury scores (Figure 1B), pulmonary edema and hemorrhage (Figures 1C, 2A), neutrophil infiltration (Figures 1D–F), IL-6 secretion (Figure 1G), and the blood flow velocity of the pulmonary circulation (Figure 2B). This evidence concerns the gene IL6 and serum lipopolysaccharide activity.