CD19 and diffuse large B-cell lymphoma: These encouraging results have prompted FDA approvals of two therapies: CTL019, a treatment for patients younger than 25 with relapsed or refractory B-cell precursor acute lymphoblastic leukemia, and another CD19-targeted CAR T-cell treatment, axicabtagene ciloleucel, for patients with failed DLBCL for at least two prior therapies (50, 51).