Combination of all three types of immunotherapy was administered in 4/30 cases: three anti-NMDAR patients (mRS 5 at admission) presenting with psychiatric symptoms, seizures and involuntary movements, and one anti-LGI1 patient (mRS 3 at admission) with FBDS, hyponatraemia, dysautonomia and insomnia required such combination. This evidence concerns the gene LGI1 and Hyponatremia.