Furthermore, when extracellular K+ was omitted (0 K+, NE-vasoconstriction value 8.36 ± 1.95 mN) to silence NKA, CPA-induced CRC and Rmax (41.56 ± 8.15%) were also significantly attenuated (p < 0.0001, Figure 5B). Here, TAC1 is linked to colorectal carcinoma.