Indeed, elevations in circulating FGF-23 levels have been shown to have a strong relationship with HF (Parker et al., 2010; Kestenbaum et al., 2014; Lutsey et al., 2014; Ferreira et al., 2019, 2020; Cheng et al., 2020; Robinson-Cohen et al., 2020). The gene discussed is FGF23; the disease is hydrops fetalis.