For instance, in chronic kidney disease (CKD), as kidney excretion capacity decreases, serum phosphate levels increase and stimulate FGF-23 synthesis, causing a rise of PTH and a deficiency of vitamin D, which can lead to adverse cardiovascular events like LVH and HF (Faul et al., 2011; Mathew et al., 2014; Navarro-García et al., 2018). This evidence concerns the gene FGF23 and chronic kidney disease.