In any case, published studies on SARS-CoV or hCoV-NL63/ACE2 show the rapidity of the internalization process since SARS-CoV/ACE2 or hCoV-NL63/ACE2 complexes are localized in early endosomes a few minutes to an hour after infection (Inoue et al., 2007; Wang et al., 2008; Milewska et al., 2018). The gene discussed is ACE2; the disease is infection.