TP53 and Insulin resistance: Targeted inhibition of p53 in adipose tissue in Trp53loxP/loxP Fabp4-Cre mice reduces inflammatory cytokine production and improves insulin resistance, while pharmacological activation of p53 stimulates lipolysis and reduces insulin-induced transport of glucose, thereby enhancing inflammation and inducing insulin resistance (Minamino et al., 2009; Vergoni et al., 2016).