In the atherosclerotic lesions of mice with ox-LDL, atherosclerotic chemokines, angiotensin II, and hypercholesterolemia, PI3K P110γ deletion reduced macrophage proliferation by inhibiting activation of the PI3K/Akt pathway in macrophages (Zotes et al., 2013). Here, PIK3CB is linked to familial hypercholesterolemia.