Oligomeric proanthocyanidins (OPCs) and epigallocatechin gallate (EGCG) promote cholesterol efflux in macrophage foam cells by activating the III PI3K/Beclin-1-mediated autophagy pathway, which may alleviate the pathological process of atherosclerosis (Jamuna et al., 2019). This evidence concerns the gene PIK3CA and atherosclerosis.