Follicle stimulating hormone promotes the expression of VCAM-1 (Figure 1) through the PI3K/Akt/mTORC2/NF-κB pathway, thereby promoting monocyte adherence to human endothelial cells, which could contribute to the follicle-stimulating hormone-induced exacerbation of atherosclerosis development in postmenopausal women (Li et al., 2017). The gene discussed is PIK3CA; the disease is atherosclerosis.