Platelet activating factor receptors and CD36 mediate atherosclerosis by activating the human monocyte/macrophage PI3K/Akt pathway to activate p38 and c-Jun-N-terminal kinase - mitogen-activated protein kinase (MAPK), increasing ox-LDL uptake and promoting foam cell formation (Rios et al., 2012). The gene discussed is PIK3CA; the disease is atherosclerosis.