Phosphatidylinositol 3 kinase (PI3K) is an intracellular kinase located on the medial side of the cell that regulates the survival, proliferation, migration, differentiation, transcription and translation of cells in the context of atherosclerosis through the activation of signaling pathways; PI3K also plays an important role in the progression and regression of atherosclerosis. The gene discussed is PIK3CB; the disease is atherosclerosis.