Reducing miR-155 (Zhai et al., 2014) andmiR-135b can effectively inhibit the PI3K/Akt/mTOR signaling pathways, enhance macrophage autophagy, and reduce plaque infiltration by macrophages, which in the early stage of atherosclerosis reduces the accumulation of foam cells and inhibits the formation and development of plaques (Wu et al., 2020). Here, PIK3CA is linked to atherosclerosis.