In addition to Akt, effectors downstream of PI3K include Ras-related C3 botulinum toxin substrate 1 (Rac1) and Protein kinase Cζ (PKCζ), but of the many of PI3K signaling pathways, the PI3K/Akt pathway is most closely related to atherosclerosis. The gene discussed is PIK3CD; the disease is atherosclerosis.