Zhu et al. (Zhu et al., 1998) showed that in Lewis rats, clomipramine (at therapeutic concentrations) significantly reduces the symptoms of experimental autoimmune neuritis, a CD4-positive T-cell-mediated autoimmune disease characterized by inflammation and demyelination and a validated animal model for the study of Guillain-Barre syndrome, a human autoimmune disease. Here, CD4 is linked to autoimmune disease.