CRF signaling may also be involved in anxiety behavior as CRF administration caused anxiety (Dunn and Berridge, 1990), whereas CRFR1 antagonists or knock-out of CRFR1 reduced anxiety-like behavior (Timpl et al., 1998; Zorrilla et al., 2002; Müller et al., 2003; Henckens et al., 2016). The gene discussed is CRH; the disease is Anxiety.