The spike binding site to HSPA5 is predicted by molecular model docking and structural bioinformatics, and revealed that the binding is more favorable at the regions III (C391-C525) and IV (C480-C488) in the spike protein 15, and region IV is the major driving force for HSPA5 binding which may be useful for developing therapeutics specific against COVID-19. This evidence concerns the gene HSPA5 and COVID-19.