GO and KEGG pathway analyses of the mRNAs associated with lnc-HLIPDA and lnc-PRND predicted that lnc-HILPDA and lnc-PRND may mediate PC-AKI through the HIF-1 and AGE-RAGE pathways (Figure 4B, C). The gene discussed is RENBP; the disease is pachyonychia congenita.