Similar to the Apcmin/+mouse model, the expression levels of pSTAT3, Cyclin D1 and C-myc were greatly elevated in the Mlkl-/-→Mlkl-/- and WT→Mlkl-/- intestinal polyps compared with the Mlkl-/-→WT and WT→WT intestinal polyps at day 80 of the AOM/DSS-induced colitis-associated tumorigenesis (Figure S3E). The gene discussed is CCND1; the disease is colitis.