Since Lgr5+ hepatocytes proliferate only briefly during injury 25, 34 and undergo less number cell division during homeostatic conditions 24, 26, the overactivation of AKT/β-catenin signaling is likely to disrupt the homeostasis of Lgr5+ hepatocytes with disastrous consequences, such as tissue proliferation in cancer. This evidence concerns the gene AKT1 and cancer.