These findings demonstrated that suppression of CEACAM6, LGR5 and Wnt signaling by CD151 silencing may revive via TGFβ1 upregulation, confirming that CD151 promotes CRC progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1. Here, LGR5 is linked to colorectal carcinoma.