GO and KEGG pathway analysis of DEGs in HT29 cells and xenografts revealed that CD151 was involved in multiple cancer signaling pathways, including the TGFβ, Wnt, Notch, Hedgehog and vascular endothelial growth factor (VEGF) signaling pathways, and regulated signal transduction effectors such as LGR5, bone morphogenetic protein 4 (BMP4) and TGFβ receptor type 1 (TGFβR1) (Figure 5). Here, LGR5 is linked to cancer.