TGFB1 and gastric cancer: Consistently, previous studies reported that regulatory T-cells (Tregs) promote LGR5 upregulation in gastric cancer cells through TGFβ1 signaling, with a likely involvement of Wnt signaling; Meanwhile, high LGR5 levels upregulated by TGFβ1 was thought to deteriorate gastric cancer patient prognosis 34.