GO enrichment analysis showed that specific proteins, including TGFβ1, adenomatous polyposis coli (APC), CTNB1, low-density lipoprotein receptor-related protein (LRP) 5 (LRP5), LRP6, JAK1, ST14, and TP53BP1, were hypothetical CD151-interacting proteins in colon cancer. This evidence concerns the gene TP53BP1 and malignant colon neoplasm.