found that oral supplementation of Bifidobacterium longum along with the fructo-oligosaccharides and modification of lifestyle, improved alanine aminotransferase level (ALT), cholesterol, TNF-α, lipoprotein, endotoxins in serum profile, improve the insulin resistance (IR) and hepatic steatosis index in NASH patients 150. The gene discussed is GPT; the disease is Insulin resistance.