hnRNPD recognizes the special substrate sequence ACUAGC in PBX1 3'-UTR and binds with it, thus stabilizing PBX1 mRNA, promoting its translation, and allowing the colony-forming cells (CFCs) to produce more CML CD34+ cells, which provides a new treatment strategy for chronic myeloid leukemia 36. Here, CD34 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.