We also transfected p53 siRNA into HCC cells and observed the level of cell viability between doxorubicin treatment alone and the miR-26b mimic plus doxorubicin treatment, revealing that the effect of miR-26b mimic enhanced doxorubicin sensitivity in HCC cells was inhibited following transfection with p53 siRNA (Figure 2B-E). This evidence concerns the gene TP53 and hepatocellular carcinoma.