In conclusion, we validate Linc-KILH as a tumor promoting lncRNA, which is up-regulated in HCC tissues and could act as a molecular regulator of KRT19 to heighten Notch1 signaling, and in turn enhances the growth and metastasis abilities of KRT19 positive HCC cells, consequently boosting the development of HCC. The gene discussed is NOTCH1; the disease is hepatocellular carcinoma.