We identified a KRT19 interacting lncRNA Linc-KILH, which specifically binds to KRT19 and restrains its phosphorylation, thus inhibiting the membrane translocation of KRT19 and then enhancing the combining capacity between KRT19 and β-catenin, which eventually stabilizes and enhances the promoting function of KRT19 on Notch1 pathway in HCC. Here, NOTCH1 is linked to hepatocellular carcinoma.