Overall, 25 differently expressed lncRNAs (LINC01963, AL357033.4, LINC01980, AL132989.1, AATBC, ELF3-AS1, AC135050.6, AL161431.1, AC106820.3, AL451085.2, AC007991.2, AC136475.2, AC012467.2, AC144831.1, AC116914.2, AC008115.3, PSMA3-AS1, PCED1B-AS1, AL139158.2, EP300-AS1, AC104083.1, AL022328.2, AC012640.2, PAX8-AS1, and AL450992.2) were found to be independent prognosis predictors of HNSCC (Table S5). The gene discussed is EP300; the disease is head and neck squamous cell carcinoma.