Biological processes associated with combination therapy-response SOX2 targets, such as “Metabolism of Proteins”, “miRNA Biogenesis”, “Protein ubiquitination”, “Cellular Responses to Stress”, “Signaling by NOTCH1 in Cancer” and “Cell Cycle, Mitotic”, were potentially responsible for the crosstalk between AZD2281 and downstream irradiation effects via SOX2 targets. This evidence concerns the gene SOX2 and cancer.