By contrast, although combination of TGFβ pathway with IFNα or IFNγ also archived more significant overall HR than individual pathways in HER2-enriched BC (Fig. 4A), we found the combination effects were only present in cohort 2 but not in the other 2 cohorts (Fig. 4C, Fig. 2A and B). Here, ERBB2 is linked to breast cancer.