In BLBC, the combination of TGFβ pathway with either IFNα, IFNγ or TNFα pathways archived more significant overall HR (HR = 0.73, 0.69, 0.70, and p = 5.95E-08, 4.92E-11, 1.04E-09 for the 3 combinations, respectively) with respect to the association with cancer recurrence than the 4 individual pathways (HR = 1.23, 0.85, 0.77, 0.83, and p = 1.85E-07, 4.95E-03, 4.26E-06, 5.96E-04, respectively) (Fig. 4A). The gene discussed is TNF; the disease is cancer.