Multivariate regression analysis revealed that the association of IFNα, IFNγ, TNFα and TGFβ pathways with recurrence risk remain significant in BLBC after adjusting for different clinical variables including age, tumor grade and size, and status of lymph node, estrogen receptor (ER), progesterone receptor (PR) and HER2 in the three cohorts (Supplementary Fig. S3). Here, ESR1 is linked to neoplasm.