More specifically, the wound healing process implemented by the liver parenchyma in response to focal thermal ablation is characterized by an intense perifocal inflammation and a progressive deposition of structural proteins (in particular collagen and elastin) in the periablational rim resulting in a profound remodeling of the extracellular matrix with dramatic changes in the mechanical properties of the tumor microenvironment6,16,29. This evidence concerns the gene ELN and neoplasm.