Of note, none of the stable myeloma precursor condition cases had any SVs involving the MYC/PVT1 hotspot13,20 in sharp contrast with 35% (6/17) in progressive precursor condition cases and 32/80 (40%) MM (Fisher’s exact test p = 0.03 and p = 0.003, respectively). This evidence concerns the gene PVT1 and Miyoshi myopathy.