TP53 and Miyoshi myopathy: The application of fluorescence in situ hybridization (FISH), single nucleotide polymorphism (SNP) array, and gene expression technologies showed that groups of MGUS/SMM patients with presence of certain genomic aberrations [e.g., del17p13 (TP53), t(4;14)(MMSET;IGH)] and expression signatures have shorten time to MM progression, when compared to groups of MGUS/SMM patients without these aberrations and/or expression signatures15,16,18,51,52.