Actin-activated ATPase assays showed that the phosphomimetic mutation T417D located in the hypertrophic cardiomyopathy (HCM) loop of the PfMyoA heavy chain (at the TEDS site)23 resulted in a ~3-fold enhancement in actin binding affinity while Vmax is unchanged24. Here, DNAH8 is linked to hypertrophic cardiomyopathy.