All subjects regardless of treatment exhibited deviation from baseline hematological and serum analyte parameters, including lymphocytopenia, generalized granulocytosis (indicated by increased neutrophils with or without concurrent increases in eosinophils and basophils), thrombocytopenia, and increases in markers of liver injury (e.g., ALT, AST, GGT, ALP) and systemic inflammation (CRP) (Supplementary Table 1 and Supplementary Fig. 2). This evidence concerns the gene CRP and Thrombocytopenia.