APC and Familial adenomatous polyposis: To validate the results obtained in cellulo, we performed in vivo experiments in APCMin/+ mice, which are heterozygous for a missense mutation in the APC gene and model human familial adenomatous polyposis (FAP) as they develop multiple intestinal polyps that acquire carcinoma features after exposure to the carcinogen drug azoxymethane (AOM)28.