TCLlnc1/HNRNPD/YBX1 complex upregulated transcription of TGFB2 and TGFBR1 genes, activated the tumor growth factor-β signaling pathway, resulting in lymphoma progression, and might be a potential target in PTCL. The gene discussed is TGFBR1; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.