Tumor-infiltrating CD4+ T cells induced by mRIPO therapy expressed higher levels of the cytolytic effector granzyme B (GzmB) and T-bet [the Th1-promoting transcription factor that also supports T cell function33], and CD8+ T cells expressed higher levels of GzmB and IFNγ 7 days post-treatment (Fig. 7e; Supplementary Fig. 10). Here, CD4 is linked to neoplasm.