First, we confirmed that mRIPO-infected adherent peritoneal exudate cells (PEC, >90% macrophage) from CD155-tg mice induced type-I IFN-dominant cytokine patterns (relative to LPS) and activation markers similar to glioma tissue slices (Fig. 2a; Supplementary Fig. 5a). The gene discussed is PVR; the disease is central nervous system cancer.