Confirming TBK1 vs. IKKα/β dichotomy of mRIPO vs. LPS treatment, tumor homogenate cytokine analysis revealed stronger IKKα/β-driven cytokine induction by LPS (IL-6, TNF, IL-1β, IL-10), with CXCL10 (TBK1-dependent; Fig. 6) being the most prominently induced cytokine after mRIPO treatment (Fig. 7c). The gene discussed is CHUK; the disease is neoplasm.