Our major discoveries include the following: (1) discovered previously unappreciated oncogenic roles of FBXO6, thus revealing a new role of FBXO6 in the development of ovarian cancer; (2) FBXO6 directly interacted with RNASET2 to target it for ubiquitin-dependent degradation; (3) FBXO6 deficiency stabilized RNASET2 protein to prevent ovarian cancer proliferation, migration, and invasion; (4) FBXO6 was overexpressed in clinical ovarian cancer tissues and high expression of FBXO6 was associated with poor survival of ovarian cancer patients at advanced stages. The gene discussed is RNASET2; the disease is ovarian carcinoma.