For instance, a mutation in TNFAIP3 (A20) that deubiquitinate IκB kinase beta leads to hyperactivation of the NFκB pathway [24], and the patients with TNFAIP3 mutation exhibit various symptoms resembling Behcet diseases, SLE, or others. The gene discussed is TNFAIP3; the disease is systemic lupus erythematosus.