A classic example is CSF1R inhibition, which caused TAM reduction in other solid tumors [57, 58] and resulted in the elimination of ~ 95% of microglia in naïve mice [59], and while proving effective in targeting TAMs in PDGFB-driven adult glioma mouse models, it was not effective in reducing their number, but instead it changed their expression profile [60]. This evidence concerns the gene CSF1R and central nervous system cancer.