In addition, Bayik et al. suggested that the monocytic MDSCs (mMDSCs)—CD45+CD11b+Ly6C+Ly6G−I-A/I-E- were enriched in the TME of male tumor-bearing animals, while granulocytic MDSCs (gMDSCs)—CD45+CD11b+Ly6C+Ly6G− were enriched in the TME of female tumor-bearing animals, suggesting that MDSC subsets drive immunosuppression in a sex-dependent manner [137]. The gene discussed is PTPRC; the disease is neoplasm.