These data suggest that while CSF1R is not important for TAM survival in PDGFB-driven tumors, its importance for TAMs in other subtypes remains to be determined, especially in light of the recent data showing that various driver mutations in adult GBM models can create different numbers, expression profiles, and compositions of TAMs, similar to what is observed in human GBM [50, 53, 55]. The gene discussed is PDGFB; the disease is glioblastoma.