Radiographic and tissue studies of patients with GBM who were treated with Avastin or Cediranib (a small-molecule VEGFR inhibitor) support the results of enhanced tumor invasiveness and increased infiltration of tumor-promoting TAMs and other CD11b+ myeloid cells [163], similar to what was also observed in a PN mouse GBM model [156]. This evidence concerns the gene KDR and glioblastoma.