When Il-1α/β or Il-1β were genetically ablated in a mouse model of PN GBM, magnetic resonance imaging (MRI) as well as histological analyses revealed decreased cerebral edema comparable to levels achieved by DEX or anti-VEGFA treatment, suggesting that inhibition of the IL-1β-mediated pro-inflammatory pathway may be a promising alternative therapy for cerebral edema [3]. The gene discussed is VEGFA; the disease is glioblastoma.