CDKN2A and malignant peripheral nerve sheath tumor: It is also noteworthy that manifestations of neural system-related tumors such as MPNST, GBM, astrocytoma, and schwannoma were consistently reported together with families harbouring gross deletion of the CDKN2A locus and/or involving loss of an intact p14ARF [12, 13, 16, 62, 88], suggesting a constitutional deficiency of p14ARF associated with NSTs.