Indeed, Luo et al. [17] showed that IRF8 performed as a candidate tumor suppressor by inducing G2/M phase cell cycle arrest and apoptosis in MDA-MB-231 (ER-) and T47D cells (ER+), and also by inhibiting cell migration and invasion in MDA-MB-231, but not in T47D cells. The gene discussed is ESR1; the disease is neoplasm.