In addition, icaritin was reported to inhibited AFP expression through promoting the expression of miR-1270, miR-1236 and miR-620 in PLC cells [21], MiR-620, miR-1236, miR-1270 might inhibit HCC apoptosis by down-regulating expression of AFP; There are other mechanisms that are independent of p53 and AFP. The gene discussed is TP53; the disease is hepatocellular carcinoma.