Regarding expression of CD47 in tumors, overexpression of CD47 was not exhibited in all kinds of cancers, and non-overexpression has been found in gastric cancer [29] and fibrolamellar subtype of hepatocellular carcinoma [28], implying that targeting CD47 therapy might not be suitable for these types of malignancies. This evidence concerns the gene CD47 and hepatocellular carcinoma.