In line with lung cancer studies, in our analysis, the expression of MCP-1, IL-8, and COX-2 was up-regulated in the cancerous cell line in response to the infection with M.tb L4.5 sub-lineage when compared to the infection with M.tb L3-CAS1 sub-lineage (p < 0.001). The gene discussed is PTGS2; the disease is infection.